With the unlocking of the Human Genome, customized humans have become a reality. Most common diseases have been eliminated or been nearly eradicated through prenatal genetic manipulation. Humans live healthier prolonged lives with old age being pushed back to 125 years. It is truly a wonderful time to be alive.
Designer genetic constructs have assisted in developing colonies throughout the solar system. There are genetically manipulated races that inhabit Earth's Oceans, Luna, Mars, Europa, and the asteroids, each designed to allow for living in these environments with minimal artificial means.
For the right price, cosmetic manipulations are possible, animal gene mods are plentiful, as are the so called Superman mods that increase the senses and musculature, though these are mostly sponsored by the military more so than civilian market.
Cyborgs are a rarity and are mostly found among those with low grade or no insurance to cover the costs of cloned limbs and organs. Again, these mods are mostly found among the military.
All of this has brought about several philosophies, and even religions, based on the thought of what it means to be human.